Disease Overview
oralcarcinomais发lifeinoralmucosatissueofmalignant tumor，is头cervicalthe most commontumorone of，approximatelysystemicmalignant tumorof3%-5%。based on发liferegionpositioncanclassified intotonguecarcinoma, Gingivacarcinoma, Buccal mucosamucosacarcinoma、mouth底carcinoma, Palatecarcinoma, Lipcarcinomaetc.。oralcarcinomawithsquamous cell carcinomamostcommon(accounting for80%and above)，commonly occurs in40-60years oldmales，andSmoking、Alcohol consumption、Betel nut chewingetc.adverselifeClosely related to lifestyle habitsrelated。early-stagesymptomsinsidious，easybyNeglected,butifcanearly-stagefoundandtreatment，5yearsurvival ratecan达80%-90%。
Major Causes
Smoking：long-termSmokingisoralcarcinomamost importantofrisk factor，Smokingthoseincidence riskisnotSmokingthoseof5-25times。
Alcohol consumption：long-termextensiveAlcohol consumptionandSmokinghavesynergistic致carcinomaeffect，risksignificantincreasing。
Betel nut chewing: EspeciallyitsinSoutheast AsiaandChinaSouthern regions,long-termchewingbetel nutthoseincreased risk20-30times。
Viral infection: Human papillomavirustumordiseasetoxin(HPV)infection，especiallyHPV16/18type，andoral鳞carcinomarelated。
Physical irritation：residual root, Residual crown,adverserepairbodylong-termFrictionstimulationoralmucosa，canInducingcarcinomachange。
Nutritional deficiency: VitaminlifeelementA、C、Eetc.Deficiency,oralmucosaBarrierfunctionunderdecrease。
Genetic factors：haveoralcarcinomafamily historythoseincreased risk。
tumor hyperthermia+minimally invasive interventional therapy precise治oralcarcinomaof双heavyProtection
面fororalmalignant tumorofInvasion,HeilongjiangofZhangMr.choiceonetype全newofgreen therapy—tumor hyperthermiacombinedminimally invasive interventional therapytechnology。thistreatmentmethodwithlowside effectsandminimally invasive伤ascharacteristics，not onlyavoidtraditionalsurgerycancan带toofDisfigurementrisk，alsosignificantinhibittumorofdevelopment。inshortshort四monthinternal，ZhangMr.ofconditionobtaintosignificantcontrol，anewseetolife活ofhope。thisone案case，thentimeverifytumor hyperthermiaAs“fifth major tumor control modality”ofclinicalvalue，alsoastumortreatment带tomoremorecancantype。
2023year11month，Heilongjiang，59-year-oldZhangMr.sensoryIn the mouthhaveone些pain，one直sensoryisoralulcer，nothaveinAttention, directlyto2024year6month，leftCheekinternalpainaddSevere,shortshortonemonth, SwellingofthanEgg-sizedalsolarge, Ulceration at the corners of the mouthofwithCauliflower-likeoneAppearance, pus and blood draining from the corners of the mouth,everyone天not停ofDrainage,usingmouth罩also遮notHospitalized,inwhenmultiplehospitalthenDiagnosed,allsay治not，whendoctor凭experienceToldZhangMr., Shouldthisis患upperoralmalignant tumor。
2024year7month，ZhangMr.totoDepartment of Oncology, Shenzhen Huaqiao Hospital，aftersystemexaminationbiopsypathologicalshow，most终confirmed diagnosisas颊internalregionmalignant tumor。along withposterior，Department of Oncology, Shenzhen Huaqiao HospitalMDTexpertgroupasZhangMr.performedconsultation，due toZhangMr.oftumorin面region，dosurgeryof话then要resectionHalf of the face,whiletraditionalradiotherapyalsoWould result intounder颌typecloseArthritisetc.side effects, WouldcausingpatientsZhangDifficulty opening mouthdifficult，comprehensiveConsiderposteriorDecidedasitsperformedtumor hyperthermiacombinedminimally invasive interventional therapytreatmentplan。present，ZhangMr.alreadytreatmentNo.6Treatment course,lesion处paincomplete remission, Purulent dischargeconditiondisappearance，hardsignificantshrinkage, Stiffnesshard程degreelarge幅relief。
ZhangMr.inaccepted记thoseinterviewtimestated: “Inot夸ZhangOh,Iis亲body验toof，thisisonceonechange，onceonechange，topresentalsothenFour to fivemonth，canrecoverytothis程degree，verySatisfied!everyonceTreatment course completed,itallsmalloneSomewhat,No.onceinterventional therapyaddupperthishyperthermia，haveThree to four days,oralinternalthengood像thattypetumorofthattypeFragmented, earlyupperone漱mouth全regionallSpit outto，theneffectone夜of间thenverysignificant, Wehospitalgoodmorepatientsseetoallsay，thiseffectistruegood，large家allcanDirectly visibleupperallcanseeobtain出to，ItrueofveryAdmiredthishospital，trueoftooSatisfied!”
tumor hyperthermiadue toitsnoPain,noside effects、safecomfortable、effectsignificantofadvantageby誉as“tumorgreen therapy”.tumorand放chemotherapy联usingtime，not onlycanrisetoincrease敏increase效ofeffect，meanwhilealsocanreducechemotherapyproduceoftoxicity and side effects。
whiletumorinterventional therapycanpreciseeffectintumorregionposition，fastRapid elimination,controltumor，forpatientsbodyimpactsmall，recoveryrapidly。
willtumor hyperthermiaandinterventional therapy结combineenablingusing，canenoughadvanceone步elevatingtreatmentof整bodyeffect. PossessesbodywhileSpeaking,hyperthermiacanwithimprovementtumor微environmental，improvetumorforlocaltreatmentofreaction。thisimprovementenablingobtaininterventional therapyinperfusionofchemotherapydrug浓degreeobtainwithimprove，fromwhiledrugoftreatmenteffectalsothenmorestrong。in addition，hyperthermiaofapplicationalsocanenoughreduceinterventionalperfusionchemotherapydrug带tooftoxicity and side effects，enablingpatientsintreatmentduring the procedurebody验moreascomfortable。
Common Symptoms
early-stagesymptoms：
oralmucosaleukoplakia、erythroplakiaorrough thickening
smallulcerlong-termnot愈combine
mildpainordifferentfeel
progressive-stagesymptoms：
persistentpain：tumorincreaselargeorSecondaryinfectioncausing
bleeding：ulcersurfacebleedingorSpontaneoustypebleeding
mass：oralinternalorcervical触andmass
dysphagia：Tumor invadestongueormouth底impactfunction
Speech impairment:tonguecarcinomacausingtonguemotorreceive限
颈lymph nodesenlargement：ipsilateralorbilateralcervicallymph nodesfirm、fixed
Classification and Staging
Pathological Classification
squamous cell carcinoma(accounting for80%-90%)：degree of differentiationfromwell-differentiatedtoundifferentiated
glandularcarcinoma：relativelyrare，such as黏fluidEpidermoidcarcinoma、glandularAdenoid cystictypecarcinoma
undifferentiated carcinoma：high degree of malignancy
othertype：verrucous carcinoma、basal cell carcinomaetc.
TNM Staging(AJCC8th edition)
Primary Tumor (T)
Tis：Carcinoma in situ
T1：tumormaximum diameter≤2cm，depth of invasion≤5mm
T2：tumor>2cmbut≤4cm，oranysizedepth of invasion>5mmand≤10mm
T3：tumor>4cm，oranysizedepth of invasion>10mm
T4a：Tumor invadesAdjacentstructure(such as皮bone、tongueexternalMuscle,skin)
T4b：Tumor invadeschewingIntermuscular spaces, pterygoid platesorskull baseand/orEncasing the carotid arteryinternalmove脉
Regional Lymph Nodes (N)
N0：No regional lymph node metastasis
N1：ipsilateral单lymph nodesmetastasis，≤3cm
N2：ipsilateralmorelymph nodesmetastasis≤6cm，orcontralaterallymph nodes≤6cm
N3：metastasislymph nodes>6cm
Distant Metastasis (M)
M0：No distant metastasis
M1：Distant metastasis present
Clinical Stage Grouping
0stage：TisN0M0
Ⅰstage：T1N0M0
Ⅱstage：T2N0M0
Ⅲstage：T3N0M0，T1-3N1M0
ⅣAstage：T4aN0-2M0，anyTN1-3M0
ⅣBstage：T4banyNM0，anyTN1-3M1
Diagnosis
oralexamination: Visual inspection, palpationfoundlesion
biopsypathological：gold standard
Imaging studies：ultrasound、CT、MRIassessmentdepth of invasionandlymph nodes
颈lymph nodesassessment：clinicalPalpationorimagingexamination
Prevention and Follow-up
quit smoking and limit alcohol：mosteffectiveofpreventionmeasures
Refusedbetel nut：avoidlong-termchewing
oral卫life：regularlyoralexamination，andtimehandleresidual root、adverserepairbody
healthy diet：more吃newFresh fruits and vegetables,reducepickled、smoked and grilledfood品
HPVVaccinationtype：canpreventionrelatedorallesion
follow-up：after treatmentfirst 2 yearsevery 3 monthsonce，years 3-5every 6 monthsonce，after 5 yearsannuallyonce